Lon-TK

• Target :

  PD-1/PD-L1

• Related Pathways :

  Cell Cycle/Checkpoint|||Apoptosis|||Immunology/Inflammation

• Bioactivity :

  Lon-TK is a glycolysis inhibitor of LTB, linked with a linker conjugate. LTB is an intelligent responsive prodrug, comprised of Lonidamine (Lon) and a PD-L1 inhibitor (BMS-1), which are connected through a thioketal linkage. It effectively inhibits glycolytic metabolism in tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK holds potential for use in photodynamic-enhanced immunotherapy research.

• Molecular Formula :

  C24H28Cl2N2O3S2

• Molecular Weight :

  527.53

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C