PT-129

• Target :

  GTPase

• Related Pathways :

  GPCR/G Protein

• Bioactivity :

  PT-129 is a PROTAC degrader targeting the NTF2 domain of G3BP1/2, capable of inhibiting and degrading stress granules in stressed cells, disrupting ATF4 trafficking, and suppressing fibroblast-mediated cancer cell proliferation.

• Smiles :

  O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C=CC=C3NCCOCCOCCOCCC(NC4=CC=C(NC([C@H](CC5=CC=CC=C5)NS(=O)(CC(N6C(C=CC=C7)=C7C=N6)=O)=O)=O)C=C4)=O

• Molecular Formula :

  C46H48N8O12S

• Molecular Weight :

  936.98

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C