Lon-TK
CAT:
804-HY-169436
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Lon-TK
- UNSPSC Description: Lon-TK is a glycolysis inhibitor + linker conjugate of LTB (HY-169434). LTB is an intelligent responsive prodrug that connects Lonidamine (Lon) (HY-B0486) and a PD-L1 inhibitor (BMS-1, HY-19991) through a thioketal linker. It significantly inhibits the glycolytic metabolism of tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK shows potential for application in photodynamic-enhanced immunotherapy research[1].
- Target Antigen: PD-1/PD-L1
- Type: Reference compound
- Related Pathways: Immunology/Inflammation
- Field of Research: Cancer;Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/lon-tk.html
- Smiles: OCCCSC(C)(SCCCOC(C1=NN(C2=C1C=CC=C2)CC3=CC=C(C=C3Cl)Cl)=O)C
- Molecular Weight: 527.53
- References & Citations: [1]Zhang Y, et al. Novel co-delivery nanomedicine for photodynamic enlarged immunotherapy by cascade immune activation and efficient Immunosuppression reversion. Bioorg Chem. 2024 Dec;153:107978.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported