Lon-TK

• Description:

  Lon-TK is a glycolysis inhibitor + linker conjugate of LTB (HY-169434) . LTB is an intelligent responsive prodrug that connects Lonidamine (Lon) (HY-B0486) and a PD-L1 inhibitor (BMS-1, HY-19991) through a thioketal linker. It significantly inhibits the glycolytic metabolism of tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK shows potential for application in photodynamic-enhanced immunotherapy research[1].

• UNSPSC:

  12352005

• Target:

  PD-1/PD-L1

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/lon-tk.html

• Smiles:

  OCCCSC(C)(SCCCOC(C1=NN(C2=C1C=CC=C2)CC3=CC=C(C=C3Cl)Cl)=O)C

• Molecular Formula:

  C24H28Cl2N2O3S2

• Molecular Weight:

  527.53

• References & Citations:

  [1]Zhang Y, et al. Novel co-delivery nanomedicine for photodynamic enlarged immunotherapy by cascade immune activation and efficient Immunosuppression reversion. Bioorg Chem. 2024 Dec;153:107978.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported