Lon-TK

CAT: 0804-HY-169436Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-169436Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lon-TK is a glycolysis inhibitor + linker conjugate of LTB (HY-169434) . LTB is an intelligent responsive prodrug that connects Lonidamine (Lon) (HY-B0486) and a PD-L1 inhibitor (BMS-1, HY-19991) through a thioketal linker. It significantly inhibits the glycolytic metabolism of tumor cells and blocks the PD-1/PD-L1 immune escape pathway. Lon-TK shows potential for application in photodynamic-enhanced immunotherapy research[1].
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lon-tk.html
Smiles
OCCCSC(C)(SCCCOC(C1=NN(C2=C1C=CC=C2)CC3=CC=C(C=C3Cl)Cl)=O)C
Molecular Formula
C24H28Cl2N2O3S2
Molecular Weight
527.53
References & Citations
[1]Zhang Y, et al. Novel co-delivery nanomedicine for photodynamic enlarged immunotherapy by cascade immune activation and efficient Immunosuppression reversion. Bioorg Chem. 2024 Dec;153:107978.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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