GA-017

CAT: 0931-T60013-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T60013-02Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2351906-74-4

Target

Others, YAP

Related Pathways

Stem Cells, Others

Purity

0.9938

Bioactivity

GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAP/TAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1].

Smiles

CC\C(=N\NC(=O)NCc1cccc(O)c1)c1ccc(O)c(C)c1O

Molecular Formula

C18H21N3O4

Molecular Weight

343.38

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

CID 147467531

CAS Number	2351906-74-4
PubChem CID	147467531
IUPAC Name	1-[(Z)-1-(2,4-dihydroxy-3-methylphenyl)propylideneamino]-3-[(3-hydroxyphenyl)methyl]urea
Molecular Formula	C18H21N3O4
Molecular Weight	343.4
XLogP	2.5
Topological Polar Surface Area	114
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Heavy Atom Count	25
Formal Charge	0
Complexity	471

SMILES

CC/C(=N/NC(=O)NCC1=CC(=CC=C1)O)/C2=C(C(=C(C=C2)O)C)O

InChI

InChI=1S/C18H21N3O4/c1-3-15(14-7-8-16(23)11(2)17(14)24)20-21-18(25)19-10-12-5-4-6-13(22)9-12/h4-9,22-24H,3,10H2,1-2H3,(H2,19,21,25)/b20-15-

InChIKey

FBCPIOAXERAOIA-HKWRFOASSA-N

Chemical Structure

2D Structure

CAS: 2351906-74-4

CID: 147467531

Formula: C18H21N3O4

MW: 343.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	343.4
XLogP3	2.5
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	343.15320616
Monoisotopic Mass	343.15320616
Topological Polar Surface Area	114 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	471
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T210882-01	MXC-017
T24216-01	JTC-017
TP1958	PL-017
T34657	SL-017
T75919-01	PL-017 TFA
T203386-01	Pro-GA
T201173-01	GA 0113
T11115-01	Duocarmycin GA
T74882-01	DOPE-GA
T201823-01	Ga-CY03

Alternative Products

Catalog	Name
BA9120-10	GA-017
GTR19281005-01	AND-017
abx085044-01	GA-PEG-GA
HO012012-1K-01	GA-PEG-GA, 1K
HY-174212	MXC-017
HY-121642	SL-017
MBS5773967	JTC-017

GA-017

Chemical Information

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