GA 0113

• Target:

  RAAS

• Related Pathways:

  Endocrinology/Hormones

• Bioactivity:

  GA 0113 is an effective orally active antagonist of the angiotensin II (Ang II) AT1 receptor. It inhibits the hypertensive response induced by Ang II, with an ID50 of 0.032 mg/kg, and dose-dependently increases plasma renin activity for up to 48 hours.

• Smiles:

  O=S(=O)(NC=1C=CC=CC1C2=NC=3C=CC(=CC3C=C2)CN4C5=NC(=CC(=C5N=C4CC)C)C)C(F)(F)F

• Molecular Formula:

  C27H24F3N5O2S

• Molecular Weight:

  539.57

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  200639-61-8