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GA-017

CAT: 0931-T60013-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T60013-01Size:1 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2351906-74-4
Target
Others|||YAP
Related Pathways
Stem Cells|||Others
Purity
0.9938
Bioactivity
GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAP/TAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1].
Smiles
CC\C(=N\NC(=O)NCc1cccc(O)c1)c1ccc(O)c(C)c1O
Molecular Formula
C18H21N3O4
Molecular Weight
343.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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