GA-017

• Target:

  Others|||YAP

• Related Pathways:

  Stem Cells|||Others

• Purity:

  0.9938

• Bioactivity:

  GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAP/TAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1].

• Smiles:

  CC\C (=N\NC (=O) NCc1cccc (O) c1) c1ccc (O) c (C) c1O

• Molecular Formula:

  C18H21N3O4

• Molecular Weight:

  343.38

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2351906-74-4