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Taletrectinib free base

CAT: 0931-T38995-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T38995-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1505514-27-1
Target
ROS Kinase
Related Pathways
Tyrosine Kinase/Adaptors
Purity
0.9998
Bioactivity
Taletrectinib free base (AB-106 free base) is a novel potent, selective and orally active ROS1/NTRK inhibitor.Taletrectinib free base has potent inhibitory effects on recombinant ROS1, NTRK1, NTRK2, and NTRK3, with IC50s of 0.207, 0.622, 2.28 and 0.98 nM, respectively, Taletrectinib free base also inhibited ROS1 G2032R and other Crizotinib-resistant ROS1 mutations.
Smiles
N([C@H](C)C1=CC(F)=CC=C1)C2=NN3C(=CN=C3C=C2)C4=CC=C(OC[C@@H](C)N)C=C4
Molecular Formula
C23H24FN5O
Molecular Weight
405.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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