CAY10502

CAT: 0931-T37556-01Size: 500 µgDry Ice: NoHazardous: No

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CAT#:0931-T37556-01Size:500 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

888320-29-4

Target

Phospholipase, Others

Related Pathways

Metabolism, Others

Bioactivity

Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway. CAY10502 is a potent inhibitor of calcium-dependent cytosolic PLA2α (cPLA2α) with an IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.

Smiles

CCCCCCCCCCOc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1

Molecular Formula

C30H37NO7

Molecular Weight

523.62

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

1-[3-(4-Decoxyphenoxy)-2-oxopropyl]-3-methoxycarbonylindole-5-carboxylic acid

CAS Number	888320-29-4
PubChem CID	11670893
IUPAC Name	1-[3-(4-decoxyphenoxy)-2-oxopropyl]-3-methoxycarbonylindole-5-carboxylic acid
Molecular Formula	C30H37NO7
Molecular Weight	523.6
XLogP	7.4
Topological Polar Surface Area	104
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	18
Heavy Atom Count	38
Formal Charge	0
Complexity	736

SMILES

CCCCCCCCCCOC1=CC=C(C=C1)OCC(=O)CN2C=C(C3=C2C=CC(=C3)C(=O)O)C(=O)OC

InChI

InChI=1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34)

InChIKey

NXDZVUAKVFVDSL-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 888320-29-4

CID: 11670893

Formula: C30H37NO7

MW: 523.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	523.6
XLogP3	7.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	18
Exact Mass	523.25700252
Monoisotopic Mass	523.25700252
Topological Polar Surface Area	104 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	736
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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BA8260-1	CAY10502

CAY10502

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