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CAY10703

CAT: 0931-T37355-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T37355-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1841421-67-7
Target
Apoptosis|||Others
Related Pathways
Apoptosis|||Others
Bioactivity
Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases. CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA. It is approximately 3-fold less cytotoxic than DCA against peripheral blood mononuclear cells from healthy blood donors. CAY10703 significantly reduces both basal and maximal respiration in leukemia cells. It is stable in vivo after subcutaneous inoculation, remaining in circulation for more than five hours after injection.
Smiles
N(CCNC(C(Cl)Cl)=O)(CCNC(C(Cl)Cl)=O)CCNC(C(Cl)Cl)=O
Molecular Formula
C12H18Cl6N4O3
Molecular Weight
479.01
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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MBS5798276CAY10703
BUP08466-01CAY10703 HCl

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