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CAY10508

CAT: 0931-T84518-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84518-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
878533-35-8
Target
Others, Cannabinoid Receptor
Related Pathways
Others, GPCR/G Protein
Bioactivity
CAY10508 is a potent and selective inverse agonist for the central cannabinoid (CB1) receptor with therapeutic potential for treating obesity and drug dependence, lacking psychotropic effects. It exhibits a Ki value of 243 nM and an EC50 of 195 nM. At a concentration of 10 μM, CAY10508 displaces [3H]-CP-55,940 with 100% efficacy at the CB1 receptor and 35% at the peripheral cannabinoid (CB2) receptor. Its inverse agonist activity at the CB1 receptor was confirmed through a [35S]-GTPγS binding assay.
Smiles
O=C1C(N(C(=O)N1C2=CC=C(Br)C=C2)C3=CC=C(Br)C=C3)C4=CC=CC=C4
Molecular Formula
C21H14Br2N2O2
Molecular Weight
486.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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