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CAY10508

CAT: 0931-T84518-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84518-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
878533-35-8
Target
Others, Cannabinoid Receptor
Related Pathways
Others, GPCR/G Protein
Bioactivity
CAY10508 is a potent and selective inverse agonist for the central cannabinoid (CB1) receptor with therapeutic potential for treating obesity and drug dependence, lacking psychotropic effects. It exhibits a Ki value of 243 nM and an EC50 of 195 nM. At a concentration of 10 μM, CAY10508 displaces [3H]-CP-55,940 with 100% efficacy at the CB1 receptor and 35% at the peripheral cannabinoid (CB2) receptor. Its inverse agonist activity at the CB1 receptor was confirmed through a [35S]-GTPγS binding assay.
Smiles
O=C1C(N(C(=O)N1C2=CC=C(Br)C=C2)C3=CC=C(Br)C=C3)C4=CC=CC=C4
Molecular Formula
C21H14Br2N2O2
Molecular Weight
486.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

1,3-Bis(4-bromophenyl)-5-phenylimidazolidine-2,4-dione

a CB1 receptor inverse agonist/antagonist; structure in first source

CAS Number878533-35-8
PubChem CID11851013
IUPAC Name1,3-bis(4-bromophenyl)-5-phenylimidazolidine-2,4-dione
Molecular FormulaC21H14Br2N2O2
Molecular Weight486.2
XLogP5.5
Topological Polar Surface Area40.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity550
SMILES
C1=CC=C(C=C1)C2C(=O)N(C(=O)N2C3=CC=C(C=C3)Br)C4=CC=C(C=C4)Br
InChI
InChI=1S/C21H14Br2N2O2/c22-15-6-10-17(11-7-15)24-19(14-4-2-1-3-5-14)20(26)25(21(24)27)18-12-8-16(23)9-13-18/h1-13,19H
InChIKey
ROASQEPZAKGACK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,3-Bis(4-bromophenyl)-5-phenylimidazolidine-2,4-dione
CAS: 878533-35-8
CID: 11851013
Formula: C21H14Br2N2O2
MW: 486.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight486.2
XLogP35.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass485.94015
Monoisotopic Mass483.94220
Topological Polar Surface Area40.6 Ų
Heavy Atom Count27
Formal Charge0
Complexity550
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
GTR19232823-01CAY10508

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