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CAY10602

CAT: 0931-T4062-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T4062-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
374922-43-7
Target
Sirtuin
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic
Purity
>99.99%
Bioactivity
CAY10602 is a SIRT1 activator derived from high throughput screening for compounds that enhance SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays indicate that CAY10602 dose-dependently suppresses NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, achieving approximately 75% inhibition at 60 μM without cytotoxicity.
Smiles
Nc1c(c2nc3ccccc3nc2n1-c1ccc(F)cc1)S(=O)(=O)c1ccccc1
Molecular Formula
C22H15FN4O2S
Molecular Weight
418.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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M18489-01CAY10602
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