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CAY10512

CAT: 0931-T35986-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T35986-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
139141-12-1
Target
NF-κB, Others
Related Pathways
NF-κB, Others
Bioactivity
The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 μM compared to 20 μM by resveratrol.
Smiles
COc1ccc(\C=C\c2ccccc2F)cc1
Molecular Formula
C15H13FO
Molecular Weight
228.266
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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