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HDAC3 inhibitor PT3

CAT: 0013-GTR19236642Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19236642Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC3 inhibitor PT3 is a novel potent, selective, BBB-permeable HDAC3 inhibitor.PT3 exhibited higher selectivity for HDAC3 over HDAC1, HDAC6, and HDAC8 compared to the reference compound CI994.PT3 upregulated H3K9 acetylation, CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43 and MMP9 expression in mouse neuronal (N2A) cells.PT3 significantly improved the discrimination index in C57/BL6 mice in the novel object recognition (NOR) model, significant increased in H3K9 acetylation in hippocampus.PT3 upregulated CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43, PSD 95 and MMP9 expression in mice treated with PT3.
CAS Number
2710273-81-5
Field of Research
Epigenetics & Chromatin; Pharmacology & Drug Discovery
Purity
>98%
Smiles
C1 (C (NC2=CC=CC=C2N) =O) =NC=C (NCC2=CC=CC=C2) N=C1
Molecular Formula
C18H17N5O
Molecular Weight
319.360482931137
Notes
For research use only.

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