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S-8510 free base

CAT: 0931-T28653-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T28653-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
151224-83-8
Target
GABA Receptor, Others
Related Pathways
Membrane transporter/Ion channel, Neuroscience, Others
Bioactivity
S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ameliorated memory impairment induced by cholinergic deficit in the water maze paradigm of Wistar rats. S-8510 augmented LTP of the Schaffer collateral/commissural fiber-CA1 synapses in the hippocampal slice preparations of SD rat. S-8510 increased the extracellular levels of acetylcholine and noradrenaline in the hippocampus of Wistar rat.
Smiles
C=12C3=C(N=CC1N=C(N2)C=4C=CON4)CCOC3
Molecular Formula
C12H10N4O2
Molecular Weight
242.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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