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S-8510 (free base)

CAT: 0804-HY-114685Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114685Size:1 Each
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Description
S-8510 free base is an inverse Benzodiazepine (BDZ) receptor agonist, with Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively.
CAS Number
151224-83-8
Product Name Alternative
SB-737552 (free base)
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-8510-free-base.html
Smiles
C12=NC=C3C(NC(C4=NOC=C4)=N3)=C1COCC2
Molecular Formula
C12H10N4O2
Molecular Weight
242.23
References & Citations
[1]Kawasaki K, et al. A novel benzodiazepine inverse agonist, S-8510, as a cognitive enhancer. Prog Neuropsychopharmacol Biol Psychiatry. 1996 Nov;20 (8) :1413-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

Chemical Information

S-8510

S-8510 / SB-737552 is a BZD inverse agonist investigated for the treatment of Alzheimer’s disease and mild to moderate senile dementia. It was being codeveloped by Shionogi and GlaxoSmithKline.

CAS Number151224-83-8
PubChem CID135409387
IUPAC Name4-(1,2-oxazol-3-yl)-12-oxa-3,5,8-triazatricyclo[7.4.0.02,6]trideca-1,3,6,8-tetraene
Molecular FormulaC12H10N4O2
Molecular Weight242.23
XLogP0.3
Topological Polar Surface Area76.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count18
Formal Charge0
Complexity316
SMILES
C1COCC2=C3C(=CN=C21)NC(=N3)C4=NOC=C4
InChI
InChI=1S/C12H10N4O2/c1-3-17-6-7-8(1)13-5-10-11(7)15-12(14-10)9-2-4-18-16-9/h2,4-5H,1,3,6H2,(H,14,15)
InChIKey
ITPFSYAYHHPKRT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of S-8510
CAS: 151224-83-8
CID: 135409387
Formula: C12H10N4O2
MW: 242.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight242.23
XLogP30.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass242.08037557
Monoisotopic Mass242.08037557
Topological Polar Surface Area76.8 Ų
Heavy Atom Count18
Formal Charge0
Complexity316
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS5778330S-8510 free base
555868(S,R,S)-AHPC free base
A22481-50(S, R, S) -AHPC free base 50mg
A22481-5(S, R, S) -AHPC free base 5mg
A22481-5000(S, R, S) -AHPC free base 5g
A22481-25(S, R, S) -AHPC free base 25mg
A22481-500(S, R, S) -AHPC free base 500mg
A22481-100(S, R, S) -AHPC free base 100mg
A22481-10(S, R, S) -AHPC free base 10mg
A22481-1000(S, R, S) -AHPC free base 1000mg

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