SNIPER (BRD) -1

• Target:

  SNIPERs|||Epigenetic Reader Domain|||Others

• Related Pathways:

  PROTAC|||Chromatin/Epigenetic|||Others

• Bioactivity:

  SNIPER (BRD) -1 is a chemical compound composed of a derivative of the IAP antagonist LCL-161 and the BET inhibitor (+) -JQ-1, linked together. It promotes the degradation of BRD4 through the ubiquitin-proteasome pathway and effectively degrades cIAP1, cIAP2, and XIAP with IC50 values of 6.8 nM, 17 nM, and 49nM, respectively[1].

• Smiles:

  CC=1C2=C (N3C ([C@H] (CC (NCCOCCOCCOCCOC4=CC (C (=O) C=5N=C (SC5) [C@]6 (N (C ([C@@H] (NC ([C@@H] (NC) C) =O) C7CCCCC7) =O) CCC6) [H]) =CC=C4) =O) N=C2C8=CC=C (Cl) C=C8) =NN=C3C) SC1C

• Molecular Formula:

  C53H66ClN9O8S2

• Molecular Weight:

  1056.73

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2095244-54-3