BMS-986115

• Product Name Alternative:

  Notch inhibitor 1

• UNSPSC Description:

  BMS-986115 (Notch inhibitor 1) is a potent Notch inhibitor, with IC50s of 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively. Used in the research of cancer[1].

• Target Antigen:

  Notch

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling;Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bms-986115.html

• Purity:

  99.90

• Solubility:

  DMSO : 13.12 mg/mL (ultrasonic;warming;heat to 70°C)

• Smiles:

  O=C(N[C@@H]1C(NC2=C(C)C=CC=C2C(C3=CC=CC(F)=C3)=N1)=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O

• Molecular Weight:

  574.49

• References & Citations:

  [1]Ashvinikumar V. Gavai, et al. Bis(fluoroalkyl)-1,4-benzodiazepinone compounds as notch inhibitors. WO2014047372A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Clinical Information:

  Phase 1

• CAS Number:

  1584647-27-7