BMS-986115

CAT: 0804-HY-12860-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12860-01Size:1 mg
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Description
BMS-986115 (Notch inhibitor 1) is a potent Notch inhibitor, with IC50s of 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively. Used in the research of cancer[1].
CAS Number
[1584647-27-7]
Product Name Alternative
Notch inhibitor 1
UNSPSC
12352005
Target
Notch
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bms-986115.html
Purity
99.90
Solubility
DMSO : 13.12 mg/mL (ultrasonic; warming; heat to 70°C)
Smiles
O=C(N[C@@H]1C(NC2=C(C)C=CC=C2C(C3=CC=CC(F)=C3)=N1)=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O
Molecular Formula
C26H25F7N4O3
Molecular Weight
574.49
References & Citations
[1]Ashvinikumar V. Gavai, et al. Bis (fluoroalkyl) -1,4-benzodiazepinone compounds as notch inhibitors. WO2014047372A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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