BMS-986318

• Description :

  BMS-986318 is a potent nonbile acid FXR agonist with EC50s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis[1].

• UNSPSC :

  12352005

• Target :

  FXR

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/bms-986318.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CC(C(F)(F)F)=C2C=C(N3CCC4(CC3)C=C(C4)C5=C(C6CC6)ON=C5C7=C(Cl)C=NC=C7Cl)C=CC2=N1)O

• Molecular Formula :

  C30H23Cl2F3N4O3

• Molecular Weight :

  615.43

• References & Citations :

  [1]Joseph Carpenter, et al. Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis. ACS Med Chem Lett. 2021 Aug 5;12 (9) :1413-1420.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [2314378-09-9]