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BMS-986235

CAT: 0804-HY-131180-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131180-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure[1].
CAS Number
2253947-47-4
Product Name Alternative
LAR-1219
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Formyl Peptide Receptor (FPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bms-986235.html
Purity
99.74
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NC1=CC=CC=C1)N[C@@H]2C(NC[C@H]2C3=C(F)C=C(OC)C=C3F)=O
Molecular Formula
C18H17F2N3O3
Molecular Weight
361.34
Precautions
H315, H319
References & Citations
[1]Asahina Y, et al. Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure [published online ahead of print, 2020 May 24]. J Med Chem. 2020;10.1021/acs.jmedchem.9b02101.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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