CPD-39

• Description:

  CPD-39 is a potent and orally active CCND1 and CDK4 heterobifunctional PROTAC degrader. CPD-39 shows anti-proliferation. (Pink: ligand for target protein (HY-50767) ; black: linker (HY-20240) ; Blue: E3 ligase ligand (HY-168667) ) [1].

• UNSPSC:

  12352211

• Target:

  CDK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cpd-39.html

• Purity:

  98.06

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC (C1=C (C2=C (N (C1=O) C3CCCC3) N=C (N=C2) NC4=CC=C (C=N4) N5CCN (CC5) CC (NC6CC7 (CC (C7) NC8=NC (NC) =CC=C8C (NC9=NN=C (C=C9) N (C) C) =O) C6) =O) C) =O

• Molecular Formula:

  C46H57N15O4

• Molecular Weight:

  884.04

• References & Citations:

  [1]Jing Liu, et al. Compounds and methods of treating cancers. French, WO2024183798A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK4

• CAS Number:

  3055472-38-0