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CPD-1224

CAT: 0804-HY-153386-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153386-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CPD-1224 is an orally effective ALK inhibitor, a derivative of an ALK inhibitor that connects to the cereblon ligand. CPD-1224 targets the EML4-ALK oncogenic fusion protein and degrades both ALK and the mutant forms L1196M/G1202R. CPD-1224 can slow down tumor growth[1].
CAS Number
2891620-68-9
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cpd-1224.html
Purity
99.83
Solubility
DMSO : 14.29 mg/mL (ultrasonic; warming; heat to 160°C)
Smiles
ClC1=CN=C(NC2=C(OC)C=C(C3CCN(CC4CN(C5=CC=C6C(C(N(C7CCC(NC7=O)=O)C6=O)=O)=C5)C4)CC3)C(C)=C2)N=C1NC8=C(S(C(C)C)(=O)=O)C=CC=C8
Molecular Formula
C43H47ClN8O7S
Molecular Weight
855.40
References & Citations
[1]Gao Y, et al. Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions. J Med Chem. 2023 Apr 10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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