CPD-10

• UNSPSC Description:

  CPD-10 is a potent CCND1 and CDK4 PROTAC degrader. CPD-10 shows anti-proliferation. CPD-10 induces apoptosis. CPD-10 decreases the protein expression of cyclin D1, cyclin D3, CDK4, P-Rb(5807/811) in a dose-dependent manner. (Pink: ligand for target protein (HY-50767); black: linker (HY-22391); Blue: E3 ligase ligand (HY-168667))[1].

• Target Antigen:

  Apoptosis; CDK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cpd-10.html

• Smiles:

  O=C(C1=CC=C(NC)N=C1NCCCCCCCNC(CN2CCN(CC2)C3=CN=C(NC4=NC(N(C5CCCC5)C(C(C(C)=O)=C6C)=O)=C6C=N4)C=C3)=O)NC7=NN=C(N(C)C)C=C7

• Molecular Weight:

  888.07

• References & Citations:

  [1]Jing Liu, et al. Compounds and methods of treating cancers. French, WO2024183798A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3055471-57-0