CPD-10

• Description:

  CPD-10 is a potent CCND1 and CDK4 PROTAC degrader. CPD-10 shows anti-proliferation. CPD-10 induces apoptosis. CPD-10 decreases the protein expression of cyclin D1, cyclin D3, CDK4, P-Rb (5807/811) in a dose-dependent manner. (Pink: ligand for target protein (HY-50767) ; black: linker (HY-22391) ; Blue: E3 ligase ligand (HY-168667) ) [1].

• UNSPSC:

  12352211

• Target:

  Apoptosis; CDK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cpd-10.html

• Purity:

  96.69

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=CC=C (NC) N=C1NCCCCCCCNC (CN2CCN (CC2) C3=CN=C (NC4=NC (N (C5CCCC5) C (C (C (C) =O) =C6C) =O) =C6C=N4) C=C3) =O) NC7=NN=C (N (C) C) C=C7

• Molecular Formula:

  C46H61N15O4

• Molecular Weight:

  888.07

• References & Citations:

  [1]Jing Liu, et al. Compounds and methods of treating cancers. French, WO2024183798A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK4

• CAS Number:

  3055471-57-0