CPD-2828

• Description:

  CPD-2828 is an orally active and selective IRE1α inhibitor with an IC50 value of 1.2 μM. CPD-2828 is promising for research of endoplasmic reticulum stress-related diseases (e.g., cancer, neurodegenerative diseases) [1].

• UNSPSC:

  12352005

• Target:

  IRE1

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer; Neurological Disease

• Smiles:

  O=CC1=C(O)C=CC2=C1OC(C(CC(N3CCC(C4=CC=C(NC(CC5)C(NC5=O)=O)C=C4)CC3)=O)=C2C)=O

• Molecular Formula:

  C29H29N3O7

• Molecular Weight:

  531.56

• References & Citations:

  [1]Zerfas BL, et al. Structure-guided design of a truncated heterobivalent chemical probe degrader of IRE1α. RSC Med Chem. 2025 Mar 18.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IRE1α