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TMX1

CAT: 0804-HY-153385-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153385-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TMX1 is a BRD4 covalent molecular glue degrader. TMX1 selectively recruits DCAF16 to the BRD4BD2, leading to BRD4 degradation.
CAS Number
3079093-92-5
UNSPSC
12352005
Target
Apoptosis; Epigenetic Reader Domain; Molecular Glues
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tmx1.html
Purity
99.57
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C/C=C/C1=CC=C(C2=N[C@@H](CC(OC(C)(C)C)=O)C3=NN=C(C)N3C4=C2C(C)=C(C)S4)C=C1
Molecular Formula
C26H28N4O3S
Molecular Weight
476.59
References & Citations
[1]Li Y D, et al. Template-assisted covalent modification of DCAF16 enables BRD4 molecular glue degraders[J]. Cancer Research, 2023, 83 (7_Supplement) : 3424-3424.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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