Nampt degrader-2

Nampt degrader-2

• CAS Number: 3035008-40-0
• UNSPSC Description: Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades NAMPT with an IC50 of 41.9 nM. Nampt degrader-2 binds to NAMPT and VHL to form a ternary complex and subsequently induced NAMPT degradation via ubiquitin-proteasome system (UPS). Nampt degrader-2 leads to significant reduction of NAD+ and exerts potent antitumor activities[1].
• Target Antigen: NAMPT; PROTACs
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/nampt-degrader-2.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C(C1=CC=C(C=C1)C(NCC2=CN=CC=C2)=O)=NC3=C4C=C(C=C3)NC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)N4CCC
• Molecular Weight: 1052.33
• References & Citations: [1]Junfei Cheng, et al. Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT. J Med Chem. 2022 Dec 8;65(23):15725-15737.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported