NAMPT degrader-3

NAMPT degrader-3

• UNSPSC Description: NAMPT degrader-3 (compound C5) is a NAMPT degrader, depending on VHL- and proteasome manner. NAMPT degrader-3 displays cytotoxicity and inhibits A2780 cells proliferation[1].
• Target Antigen: NAMPT
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/nampt-degrader-3-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@@H](NC(CCCCCCCNC(C1=CC=C(C(N2CCC(CC2)CCCCNC(/C=C/C3=CC=CN=C3)=O)=O)C=C1)=O)=O)C(C)(C)C)N4C[C@@H](C[C@H]4C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)O
• Molecular Weight: 1003.30
• References & Citations: [1]Zhang P, et al. Discovery of potent NAMPT-Targeting PROTACs using FK866 as the warhead. Bioorg Med Chem Lett. 2023 Jun 25;92:129393.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported