NAMPT degrader-3

• UNSPSC Description:

  NAMPT degrader-3 (compound C5) is a NAMPT degrader, depending on VHL- and proteasome manner. NAMPT degrader-3 displays cytotoxicity and inhibits A2780 cells proliferation[1].

• Target Antigen:

  NAMPT

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nampt-degrader-3-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@@H](NC(CCCCCCCNC(C1=CC=C(C(N2CCC(CC2)CCCCNC(/C=C/C3=CC=CN=C3)=O)=O)C=C1)=O)=O)C(C)(C)C)N4C[C@@H](C[C@H]4C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)O

• Molecular Weight:

  1003.30

• References & Citations:

  [1]Zhang P, et al. Discovery of potent NAMPT-Targeting PROTACs using FK866 as the warhead. Bioorg Med Chem Lett. 2023 Jun 25;92:129393.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported