ITK degrader 2

• UNSPSC Description:

  ITK degrader 2 (compound 30) is an orally active, PROTAC-based ITK-targeted degrader (DC50max and Tmax in mice (po; 90 mg/kg) of 0.87 μM and 2 h, respectively. At this dose, ITK degrader 2 degrades ITK by 20% (6 h) in mice[1].

• Target Antigen:

  Itk; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/itk-degrader-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12[C@@](CC3=C(NN=C3C(NC4=C5)=CC4=CC=C5N(C)C([C@@H](N6CCN(CC6)CC7CCN(C8=CC=C(C9C(NC(CC9)=O)=O)C=N8)CC7)C)=O)C2)([H])C1(F)F

• Molecular Weight:

  753.88

• References & Citations:

  [1]Wegrzyniak, et al. Substituted piperidinedione and dioxotetrahydropyrimidine compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use. World Intellectual Property Organization, WO2022235698 A1 2022-11-10.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2858738-65-3