Products for Research Use Only
RegisterLogin

ITK degrader 2

CAT: 0804-HY-153322Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-153322Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ITK degrader 2 (compound 30) is an orally active, PROTAC-based ITK-targeted degrader (DC50max and Tmax in mice (po; 90 mg/kg) of 0.87 μM and 2 h, respectively. At this dose, ITK degrader 2 degrades ITK by 20% (6 h) in mice[1].
CAS Number
2858738-65-3
UNSPSC
12352005
Target
Itk; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/itk-degrader-2.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@@](CC3=C(NN=C3C(NC4=C5)=CC4=CC=C5N(C)C([C@@H](N6CCN(CC6)CC7CCN(C8=CC=C(C9C(NC(CC9)=O)=O)C=N8)CC7)C)=O)C2)([H])C1(F)F
Molecular Formula
C41H49F2N9O3
Molecular Weight
753.88
References & Citations
[1]Wegrzyniak, et al. Substituted piperidinedione and dioxotetrahydropyrimidine compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use. World Intellectual Property Organization, WO2022235698 A1 2022-11-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-149917ITK degrader 1
HY-128726-01ITK inhibitor 2
HY-174136STING Degrader-2
HY-163815-01CDK2 degrader 2
HY-168624-01VAV1 degrader-2
HY-178161HDAC degrader-2
HY-177725MG degrader 2
HY-156153CARM1 degrader-2
HY-177720EEF2K degrader-2
HY-W1128213IKZF2-degrader 2

Alternative Products

CatalogName
TBI5001-5MGSTING Degrader 1, STING degrader
T74545-01STAT3 degrader-1
T211896-01GSPT1 degrader-7
T211514-01Lck degrader-1
T210553-01ER degrader 11
T209932-01CDK4 degrader 1
T209911-01BRD4 degrader-2
T209877-01AR Degrader-1
T209376-01Tubulin degrader 1
T207627-01CDK9 degrader-1

Popular Products