FTO-IN-7

• Description:

  FTO-IN-7 (compound 17) is an inhibitor of FTO (fat mass and obesity-associated protein) with an IC50 of [1].

• UNSPSC:

  12352005

• Target:

  Fat Mass and Obesity-associated Protein (FTO)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fto-in-7.html

• Concentration:

  10mM

• Purity:

  99.22

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C(NC2=C(C=C(C3=C(C)NN=C3C)C=C2Cl)Cl)C=CC=C1)O

• Molecular Formula:

  C18H15Cl2N3O2

• Molecular Weight:

  376.24

• References & Citations:

  [1]Yang, Caiguang, et al.Preparation of 2-substituted-benzene matrix compounds as FTO inhibitors.China, WO2018157843.2018-09-07.|[2]Liu Z, Duan Z, Zhang D, et al. Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors. J Med Chem. 2022;65 (15) :10638-10654.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2243736-37-8