FTO-IN-12

CAT: 0804-HY-W026109Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-W026109Size:1 Each

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Description

FTO-IN-12 (Compound 2) is an inhibitor of fat mass and obesity-related protein (FTO) . Kd and IC50 values are 185 nM and 1.46 μM, respectively. FTO-IN-12 can be used in the study of neurodegenerative diseases[1].

CAS Number

955328-22-0

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Fat Mass and Obesity-associated Protein (FTO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fto-in-12.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=C(N)C2=CC=CC(Cl)=C2N=C1

Molecular Formula

C10H7ClN2O2

Molecular Weight

222.63

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Selberg S, et al. Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons. Int J Mol Sci. 2021 Apr 26;22 (9) :4537.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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HY-172399	FTO-IN-14
HY-138843	FTO-IN-1
HY-156405	FTO-IN-10
HY-132865-01	FTO-IN-3
HY-139820	FTO-IN-4

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GTR19234074-01	FTO-IN-12
523110-01	FTO
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YP-W10566-01	Human FTO (FTO) ELISA Kit
YP-W29931-01	Mouse FTO (FTO) ELISA Kit
YP-W80450-01	Porcine FTO (FTO) ELISA Kit
BA7714-10	FTO-IN-3
BA7711-25	FTO-IN-8
10R-8360	FTO antibody
T40221	FTO-IN-2

FTO-IN-12

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