FTO-IN-14

CAT: 0804-HY-172399Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172399Size:1 Each
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Description
FTO-IN-14 (Compound F97) is the inhibitor for the RNA demethylase Fat mass and obesity-associated protein FTO with IC50 of 0.45 μM. FTO-IN-14 regulates the protein expression of ASB2, RARA and MYC. FTO-IN-14 exhibits antiproliferative activity in AML cancer cells (IC50 for MOLM13, NB4, HEL, OCI-AML3, MV4-11 and MONOMAC6 is 0.7-5.5 μM), induces apoptosis in NB4 cell. FTO-IN-14 exhibits antitumor activity in mouse NB4 xenograft models[1].
UNSPSC
12352005
Target
Apoptosis; Fat Mass and Obesity-associated Protein (FTO)
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
OC(C(SC=C1)=C1NC2=C(C3CC3)C=C(C4=C(C)NN=C4C)C=C2C5CC5)=O
Molecular Formula
C22H23N3O2S
Molecular Weight
393.50
References & Citations
[1]Zhang D, et al., Development of 3-arylaminothiophenic-2-carboxylic acid derivatives as new FTO inhibitors showing potent antileukemia activities. Eur J Med Chem. 2025 Feb 25;289:117444.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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