FTO-IN-14

• Description:

  FTO-IN-14 (Compound F97) is the inhibitor for the RNA demethylase Fat mass and obesity-associated protein FTO with IC50 of 0.45 μM. FTO-IN-14 regulates the protein expression of ASB2, RARA and MYC. FTO-IN-14 exhibits antiproliferative activity in AML cancer cells (IC50 for MOLM13, NB4, HEL, OCI-AML3, MV4-11 and MONOMAC6 is 0.7-5.5 μM), induces apoptosis in NB4 cell. FTO-IN-14 exhibits antitumor activity in mouse NB4 xenograft models[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Fat Mass and Obesity-associated Protein (FTO)

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  OC(C(SC=C1)=C1NC2=C(C3CC3)C=C(C4=C(C)NN=C4C)C=C2C5CC5)=O

• Molecular Formula:

  C22H23N3O2S

• Molecular Weight:

  393.50

• References & Citations:

  [1]Zhang D, et al., Development of 3-arylaminothiophenic-2-carboxylic acid derivatives as new FTO inhibitors showing potent antileukemia activities. Eur J Med Chem. 2025 Feb 25;289:117444.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported