FTO-IN-10

FTO-IN-10

• UNSPSC Description: FTO-IN-10 (compound 7) is a potent human demethylase FTO (the fat mass and obesity-associated protein) inhibitor with an IC50 of 4.5 μM. FTO-IN-10 enters the FTO’s structural domain II binding pocket through hydrophobic and hydrogen bonding interactions. FTO-IN-10 induces DNA damage and autophagic cell death in A549 cells[1].
• Target Antigen: Autophagy; Fat Mass and Obesity-associated Protein (FTO)
• Type: Reference compound
• Related Pathways: Autophagy;Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/fto-in-10.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=CC2=CC=CC(C(N(CCN(C)C)C3=O)=O)=C2C3=C1)C4=NC=CC=C4
• Molecular Weight: 388.42
• References & Citations: [1]Chao Ge, et al. Novel 1,8-Naphthalimide Derivatives As Antitumor Agents and Potent Demethylase Inhibitors. ACS Med. Chem. Lett. 2023.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported