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FTO-IN-10

CAT: 0804-HY-156405Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156405Size:1 Each
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Description
FTO-IN-10 (compound 7) is a potent human demethylase FTO (the fat mass and obesity-associated protein) inhibitor with an IC50 of 4.5 μM. FTO-IN-10 enters the FTO’s structural domain II binding pocket through hydrophobic and hydrogen bonding interactions. FTO-IN-10 induces DNA damage and autophagic cell death in A549 cells[1].
UNSPSC
12352005
Target
Autophagy; Fat Mass and Obesity-associated Protein (FTO)
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fto-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC2=CC=CC(C(N(CCN(C)C)C3=O)=O)=C2C3=C1)C4=NC=CC=C4
Molecular Formula
C22H20N4O3
Molecular Weight
388.42
References & Citations
[1]Chao Ge, et al. Novel 1,8-Naphthalimide Derivatives As Antitumor Agents and Potent Demethylase Inhibitors. ACS Med. Chem. Lett. 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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