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FTO-IN-16

CAT: 0804-HY-179267Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179267Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FTO-IN-16 (Compound 8a-1), a FTO-IN-15 prodrug, is a potent FTO inhibitor. FTO-IN-16 suppresses acute myeloid leukemia (AML) cell viability, increases m6A levels, downregulates c-Myc and CEBPA, and upregulates ASB2 and RARA. FTO-IN-16 induces apoptosis. FTO-IN-16 demonstrates strong in vivo efficacy in AML mouse xenografts. FTO-IN-16 can be used for the research of AML[1].
UNSPSC
12352005
Target
Apoptosis; c-Myc; Fat Mass and Obesity-associated Protein (FTO) ; RAR/RXR
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=CC=CC=C1NC2=C(C=C(C=C2Cl)C(NCCNC(/C=C/C(OCC)=O)=O)=O)Cl)OC
Molecular Formula
C23H23Cl2N3O6
Molecular Weight
508.35
References & Citations
[1]Zhang X, et al. Structure-Based Design of a Highly Potent Dual-Competitive FTO Inhibitor for Targeted m6A Demethylase Inhibition in AML. J Med Chem. 2025 Nov 13;68 (21) :22779-22798.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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