GDC-0334

• Description :

  GDC-0334 is a selective TRPA1 antagonist. GDC-0334 inhibits TRPA1 function on airway smooth muscle and sensory neurons by decreasing cough and allergic airway inflammation in rats and guinea pigs. GDC-0334 can be used for TRPA1-mediated diseases research, such as pain or asthma[1][2].

• UNSPSC :

  12352005

• Target :

  TRP Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/gdc-0334.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@H]1N(S(=O)(C2=CC=C(F)C=C2)=O)[C@@H](C)[C@H](F)C1)NCC3=CC(C4=CN=C(C(F)(F)F)N=C4)=NC=C3C(F)(F)F

• Molecular Formula :

  C24H19F8N5O3S

• Molecular Weight :

  609.49

• References & Citations :

  [1]Estrada A, et al. 1- (het) arylsulfonyl- (pyrrolidine or piperidine) -2-carboxamide derivatives and their use as trpa1 antagonists. WO2016128529 A1.|[2]Balestrini A, et.al A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment. J Exp Med. 2021 Apr 5;218 (4) :e20201637.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  TRPA1

• CAS Number :

  [1984824-54-5]