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ORIC-101

CAT: 0804-HY-112710-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112710-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. Anti-cancer activity. ORIC-101 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2222344-98-9
UNSPSC
12352005
Target
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ORIC-101.html
Concentration
10mM
Purity
99.30
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CN(C(C)C)C1=CC=C([C@@H]2[C@@]([C@](CC3)([H])C(CC4)=CC3=O)([H])[C@]4([H])[C@@](CC[C@]5(C#CC(C)(C)C)O)([H])[C@]5(C)C2)C=C1
Molecular Formula
C34H47NO2
Molecular Weight
501.74
References & Citations
[1]Rew Y, et al. Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101) . J Med Chem. 2018 Sep 13;61 (17) :7767-7784.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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