ORIC-101

• Description :

  ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. Anti-cancer activity. ORIC-101 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Target :

  Glucocorticoid Receptor

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cancer; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/ORIC-101.html

• Concentration :

  10mM

• Purity :

  99.30

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  CN(C(C)C)C1=CC=C([C@@H]2[C@@]([C@](CC3)([H])C(CC4)=CC3=O)([H])[C@]4([H])[C@@](CC[C@]5(C#CC(C)(C)C)O)([H])[C@]5(C)C2)C=C1

• Molecular Formula :

  C34H47NO2

• Molecular Weight :

  501.74

• References & Citations :

  [1]Rew Y, et al. Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101) . J Med Chem. 2018 Sep 13;61 (17) :7767-7784.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [2222344-98-9]