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DU-14

CAT: 0804-HY-116377-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:HY-116377-01Size:5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM) . DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity[1][2][3].
CAS Number
[186303-55-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Steroid Sulfatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/du-14.html
Purity
99.18
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCC(NCCC1=CC=C(C=C1)OS(N)(=O)=O)=O
Molecular Formula
C22H38N2O4S
Molecular Weight
426.61
Precautions
H302, H315, H319, H335
References & Citations
[1]Selcer KW, et al. Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl) -N-alkanoyl tyramines. Cancer Res. 1997 Feb 15;57 (4) :702-7. |[2]Li PK, et al. Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl) -N-tetradecanoyl tyramine. Life Sci. 1997;60 (3) :PL45-51. |[3]Yue XH, et al. Steroid sulfatase inhibitor DU-14 protects spatial memory and synaptic plasticity from disruption by amyloid β protein in male rats. Horm Behav. 2016 Jul;83:83-92.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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