DU-14

• Description :

  DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM) . DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Steroid Sulfatase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/du-14.html

• Purity :

  99.18

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  CCCCCCCCCCCCCC(NCCC1=CC=C(C=C1)OS(N)(=O)=O)=O

• Molecular Formula :

  C22H38N2O4S

• Molecular Weight :

  426.61

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Selcer KW, et al. Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl) -N-alkanoyl tyramines. Cancer Res. 1997 Feb 15;57 (4) :702-7. |[2]Li PK, et al. Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl) -N-tetradecanoyl tyramine. Life Sci. 1997;60 (3) :PL45-51. |[3]Yue XH, et al. Steroid sulfatase inhibitor DU-14 protects spatial memory and synaptic plasticity from disruption by amyloid β protein in male rats. Horm Behav. 2016 Jul;83:83-92.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [186303-55-9]