PROTAC PTP1B degrader 1

• UNSPSC Description:

  PROTAC PTP1B degrader 1 (compound 75) is a CRBN-based PTP1B PROTAC degrader, with DC50 values of 0.2 μM (48 h) and 0.05 μM (72 h) (Red: PTP1B ligand Oleanolic acid (HY-N0156); Black: linker; Blue: CRBN ligand)[1].

• Target Antigen:

  Phosphatase; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;PROTAC

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/protac-pipib-degrader-1.html

• Smiles:

  O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(NC(CCCCCOCCOCCOCCOCCCCCCNC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@](C(C)([C@H](CC7)O)C)([H])CC8)C)([H])[C@]8(C)[C@@]6(CC4)C)=O)=O)=C3C1=O

• Molecular Weight:

  1057.40

• References & Citations:

  [1]Zunhua Yang, et al. Discovery of Selective Proteolysis-Targeting Chimera Degraders Targeting PTP1B as Long-Term Hypoglycemic Agents. J Med Chem. 2024 May 9;67(9):7569-7584.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported