PROTAC PTP1B degrader 1

PROTAC PTP1B degrader 1

• UNSPSC Description: PROTAC PTP1B degrader 1 (compound 75) is a CRBN-based PTP1B PROTAC degrader, with DC50 values of 0.2 μM (48 h) and 0.05 μM (72 h) (Red: PTP1B ligand Oleanolic acid (HY-N0156); Black: linker; Blue: CRBN ligand)[1].
• Target Antigen: Phosphatase; PROTACs
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PROTAC
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/protac-pipib-degrader-1.html
• Smiles: O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(NC(CCCCCOCCOCCOCCOCCCCCCNC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@](C(C)([C@H](CC7)O)C)([H])CC8)C)([H])[C@]8(C)[C@@]6(CC4)C)=O)=O)=C3C1=O
• Molecular Weight: 1057.40
• References & Citations: [1]Zunhua Yang, et al. Discovery of Selective Proteolysis-Targeting Chimera Degraders Targeting PTP1B as Long-Term Hypoglycemic Agents. J Med Chem. 2024 May 9;67(9):7569-7584.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported