SB-429201

• Description:

  SB-429201 is a potent and selective HDAC1 (IC50~1.5 μM) . SB-429201 displays at least a 20-fold preference for HDAC1 inhibition over HDAC3 and HDAC8[1][2].

• Product Name Alternative:

  MK-0869; MK-869; L-754030

• UNSPSC:

  12352005

• Target:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sb-429201.html

• Purity:

  98.15

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=CC=C(C(NC2=CC=C(OC3=CC=CC=C3)C=C2)=O)C=C1)CCC4=CC=CC=C4

• Molecular Formula:

  C28H24N2O3

• Molecular Weight:

  436.50

• References & Citations:

  [1]Bieliauskas AV, Pflum MK. Isoform-selective histone deacetylase inhibitors. Chem Soc Rev. 2008;37 (7) :1402-1413. |[2]Hu E, et al. Identification of novel isoform-selective inhibitors within class I histone deacetylases. J Pharmacol Exp Ther. 2003;307 (2) :720-728.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC3

• CAS Number:

  [1027971-34-1]