CFTR potentiator 1

CFTR potentiator 1

• UNSPSC Description: CFTR potentiator 1 (I1421) is a potent CFTR potentiator with an EC50 value of 64 nM. CFTR potentiator 1 allosterically activates a wide range of CF-causing mutants, such as ΔF508 and G551D CFTR[1].
• Target Antigen: CFTR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cftr-potentiator-1.html
• Smiles: NC1=NN(C([C@@H](COC2=CC=CC=C2)C)=O)C3=CC(C(N)=O)=CC=C31
• Molecular Weight: 338.36
• References & Citations: [1]Fangyu Liu, et al. Structure-based discovery of CFTR potentiators and inhibitors. Cell. 2024 May 23:S0092-8674(24)00472-0.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported