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CFTR potentiator 1

CAT: 0804-HY-161753Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161753Size:1 Each
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Description
CFTR potentiator 1 (I1421) is a potent CFTR potentiator with an EC50 value of 64 nM. CFTR potentiator 1 allosterically activates a wide range of CF-causing mutants, such as ΔF508 and G551D CFTR[1].
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cftr-potentiator-1.html
Smiles
NC1=NN(C([C@@H](COC2=CC=CC=C2)C)=O)C3=CC(C(N)=O)=CC=C31
Molecular Formula
C18H18N4O3
Molecular Weight
338.36
References & Citations
[1]Fangyu Liu, et al. Structure-based discovery of CFTR potentiators and inhibitors. Cell. 2024 May 23:S0092-8674 (24) 00472-0.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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