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CFTR corrector 13

CAT: 0804-HY-161894Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161894Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CFTR corrector 13 (SVQ18) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector (EC50=3.14 μM). CFTR corrector 13 enhances the function of CFTR channels, especially when used in combination with Lumacaftor , it can produce a dose-dependent increase in CFTR function. CFTR corrector 13 can be used in the study of cystic fibrosis (CF) and other CFTR-related diseases[1].
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cftr-corrector-13.html
Smiles
CC1=CC(CN2C(C(OCC)=O)=C(Cl)C3=C2C4=NC(NS(C5=CC=CC=C5)(=O)=O)=NC=C4CC3)=CC=C1
Molecular Formula
C27H25ClN4O4S
Molecular Weight
537.03
References & Citations
[1]Barreca, et al. "Identification of 6, 9-dihydro-5H-pyrrolo [3, 2-h] quinazolines as a new class of F508del-CFTR correctors for the treatment of cystic fibrosis." European Journal of Medicinal Chemistry (2024) : 116691.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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