CFTR corrector 12

• Description:

  CFTR corrector 12 (compound 17C) is a bithiazole derivative, serving as CFTR corrector. CFTR corrector 12 has the ability to correct some folding defective mutants of the channel responsible for the control of chloride transport across the plasma membrane. CFTR corrector 12 recovers the α-sarcoglycan (α-SG) content in mutant cells[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  CFTR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/cftr-corrector-12.html

• Concentration:

  10mM

• Purity:

  99.85

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(C)(C)C)NC1=NC(C)=C(C2=CSC(NC3=CC(Cl)=CC=C3OC)=N2)S1

• Molecular Formula:

  C19H21ClN4O2S2

• Molecular Weight:

  436.98

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Ribaudo G, et al. Synthesis and Evaluation of Bithiazole Derivatives As Potential α-Sarcoglycan Correctors. ACS Med Chem Lett. 2023 Jul 28;14 (8) :1049-1053.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [958941-60-1]