CFTR corrector 4

• Description :

  CFTR corrector 4 (Compound 13), an active (R, R) -form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis[1].

• UNSPSC :

  12352005

• Target :

  CFTR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/cftr-corrector-4.html

• Purity :

  99.72

• Solubility :

  DMSO : 110 mg/mL (ultrasonic)

• Smiles :

  O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)N[C@@H]4C[C@H](C5=CC=C(OC)C(OC)=C5)OC6=CC(OC)=CC=C46

• Molecular Formula :

  C29H27F2NO7

• Molecular Weight :

  539.52

• References & Citations :

  [1]Wang X, et al. Discovery of 4-[ (2R,4R) -4- ({[1- (2,2-Difluoro-1,3-benzodioxol-5-yl) cyclopropyl]carbonyl}amino) -7- (difluoromethoxy) -3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1918142-34-3]