CFTR(inh)-172

CFTR(inh)-172

• CAS Number: 307510-92-5
• UNSPSC Description: CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.
• Target Antigen: Autophagy; CFTR
• Type: Reference compound
• Related Pathways: Autophagy;Membrane Transporter/Ion Channel
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/CFTR_inh_-172.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: S=C(S/1)N(C2=CC=CC(C(F)(F)F)=C2)C(C1=C\C3=CC=C(C=C3)C(O)=O)=O
• Molecular Weight: 409.40
• References & Citations: [1]Ma T, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec;110(11):1651-8.|[2]Taddei A, et al. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett. 2004 Jan 30;558(1-3):52-6.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported