CFTR corrector 8

• Description:

  CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis[1].

• UNSPSC:

  12352005

• Target:

  CFTR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cftr-corrector-8.html

• Purity:

  96.00

• Solubility:

  DMSO : 110 mg/mL (ultrasonic)

• Smiles:

  COC(C=C1[C@H](C2)OC3=CC(OC)=CC=C3[C@H]2NC(C4(C5=CC=C(OC(F)(O6)F)C6=C5)CC4)=O)=C(C=C1)OC

• Molecular Formula:

  C29H27F2NO7

• Molecular Weight:

  539.52

• References & Citations:

  [1]Wang X, et al. Discovery of 4-[ (2R,4R) -4- ({[1- (2,2-Difluoro-1,3-benzodioxol-5-yl) cyclopropyl]carbonyl}amino) -7- (difluoromethoxy) -3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61 (4) :1436-1449.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1918142-35-4]