YM-16638

• Description:

  YM-16638 is an orally active leukotriene (LT) antagonist. YM-16638 can inhibit the production of LTC4, LTD4, and LTE4 in guinea pig trachea, with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. YM-16638 has a dose-dependent inhibitory effect on antigen-induced early and late respiratory responses in allergic sheep[1].

• Product Name Alternative:

  YM 638

• UNSPSC:

  12352005

• Target:

  Leukotriene Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ym-16638.html

• Smiles:

  O=C (O) CSC1=NN=C (SCCCOC2=CC=C (C (C) =O) C (O) =C2CCC) S1

• Molecular Formula:

  C18H22N2O5S3

• Molecular Weight:

  442.57

• References & Citations:

  [1]Tomioka K, et al. The effect of an orally active leukotriene (LT) antagonist YM-16638 on antigen-induced early and late airway responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids. 1989 Apr;36 (1) :43-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  104073-72-5