YM-16638

• Description :

  YM-16638 is an orally active leukotriene (LT) antagonist. YM-16638 can inhibit the production of LTC4, LTD4, and LTE4 in guinea pig trachea, with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. YM-16638 has a dose-dependent inhibitory effect on antigen-induced early and late respiratory responses in allergic sheep[1].

• Product Name Alternative :

  YM 638

• UNSPSC :

  12352005

• Target :

  Leukotriene Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ym-16638.html

• Smiles :

  O=C(O)CSC1=NN=C(SCCCOC2=CC=C(C(C)=O)C(O)=C2CCC)S1

• Molecular Formula :

  C18H22N2O5S3

• Molecular Weight :

  442.57

• References & Citations :

  [1]Tomioka K, et al. The effect of an orally active leukotriene (LT) antagonist YM-16638 on antigen-induced early and late airway responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids. 1989 Apr;36 (1) :43-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [104073-72-5]