Products for Research Use Only
RegisterLogin

HAChE-IN-9

CAT: 0804-HY-168052Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-168052Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HAChE-IN-9 (compound 7i) is a selective inhibitor of human acetylcholinesterase (hAChE) with IC50 of 0.05 μM and 2.85 μM for AChE and BChE, respectively. hAChE-IN-9 modulates toxic Aβ oligomer forms into non-toxic ones and has antioxidant and neuroprotective effects against Aβ-induced toxicity. hAChE-IN-9 can be used for the study of Alzheimer's disease[1].
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hache-in-9.html
Smiles
O=C(/C(C#N)=C(SC)/NC1=CC=C([N+]([O-])=O)C=C1)NN2C(CCl)=NC3=CC=CC=C3C2=O
Molecular Formula
C20H15ClN6O4S
Molecular Weight
470.89
References & Citations
[1]Kandrakonda Yelamanda, et al. "Quinazolinone–Hydrazine Cyanoacetamide Hybrids as Potent Multitarget-Directed Druggable Therapeutics against Alzheimer’s Disease: Design, Synthesis, and Biochemical, In Silico, and Mechanistic Analyses." ACS Chemical Neuroscience (2024) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

Related Products

CatalogName
HY-157527HAChE-IN-7
HY-155085HAChE-IN-3
HY-170583HAChE-IN-10
HY-155086HAChE-IN-4
HY-149233HAChE-IN-1
HY-155366HAChE-IN-6
HY-149237HAChE-IN-2
HY-155365HAChE-IN-5
HY-163514HAChE-IN-8
HY-170691HAChE/hBuChE-IN-1

Alternative Products

CatalogName
T200751-01HAChE-IN-9
T204876-01HAChE-IN-10
T79300-01HAChE-IN-4
T209772-01HAChE-IN-8
T86542-01HAChE-IN-7
T78689-01HAChE-IN-1
T82242-01HAChE-IN-6
MBS5820961hAChE-IN-3
MBS5820354hAChE-IN-2
GTR19218176-01HAChE-IN-5

Popular Products