HAChE-IN-7

• Target :

  Beta-Secretase|||Cholinesterase (ChE)

• Related Pathways :

  Neuroscience

• Bioactivity :

  HAChE-IN-7 (compound 5s) serves as a mixed inhibitor impacting both the catalytic active site (CAS) and peripheral anionic site (PAS) of hAChE. This compound demonstrates a balanced inhibitory effect with IC 50 values of 69.8 nM for hAChE and 68.0 nM for hBuChE. Additionally, it exhibits an inhibitory activity against ?-secretase-1 (BACE-1) with an IC 50 of 3.6 ?M. hAChE-IN-7 holds potential for research in Alzheimer's disease (AD) [1].

• Smiles :

  N(CCCCCCCOC1=C(OC)C=C(CNC(CCCCCCC(C)C)=O)C=C1)C2=C3C(=NC=4C2=CC=CC4)CCCC3

• Molecular Formula :

  C38H55N3O3

• Molecular Weight :

  601.86

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2978613-03-3