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HAChE-IN-7

CAT: 0931-T86542-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T86542-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2978613-03-3
Target
Beta-Secretase, Cholinesterase (ChE)
Related Pathways
Neuroscience
Bioactivity
HAChE-IN-7 (compound 5s) serves as a mixed inhibitor impacting both the catalytic active site (CAS) and peripheral anionic site (PAS) of hAChE. This compound demonstrates a balanced inhibitory effect with IC 50 values of 69.8 nM for hAChE and 68.0 nM for hBuChE. Additionally, it exhibits an inhibitory activity against β-secretase-1 (BACE-1) with an IC 50 of 3.6 μM. hAChE-IN-7 holds potential for research in Alzheimer's disease (AD) [1].
Smiles
N(CCCCCCCOC1=C(OC)C=C(CNC(CCCCCCC(C)C)=O)C=C1)C2=C3C(=NC=4C2=CC=CC4)CCCC3
Molecular Formula
C38H55N3O3
Molecular Weight
601.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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