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HAChE-IN-6

CAT: 0804-HY-155366Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155366Size:1 Each
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Description
HAChE-IN-6 (compound 51) is a brain penetrant AChE inhibitor with an IC50 of 0.16 μM. hAChE-IN-6 also inhibits hBuChE and GSK3β with IC50 values of 0.69 μM and 0.26 μM, respectively. hAChE-IN-6 inhibits tau protein and Aβ1-42 self-aggregation, and can be used for Alzheimer's disease (AD) research[1].
CAS Number
3007667-17-3
UNSPSC
12352005
Target
Cholinesterase (ChE) ; GSK-3
Type
Reference compound
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hache-in-6.html
Solubility
10 mM in DMSO
Smiles
NC1=NNC2=NC(C3=CC=C(Br)C=C3)=CC(C4=CC(OC)=C(OC)C=C4)=C21
Molecular Formula
C20H17BrN4O2
Molecular Weight
425.28
References & Citations
[1]Omnia M Waly, et al. Multi-targeted anti-Alzheimer's agents: Synthesis, biological evaluation, and molecular modeling study of some pyrazolopyridine hybrids. Eur J Med Chem. 2023 Oct 20:262:115880.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; GSK-3β

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