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HAChE-IN-5

CAT: 0804-HY-155365Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155365Size:1 Each
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Description
HAChE-IN-5 (compound 49) is a potent hAChE and hBuChE inhibitor with IC50 values of 0.17 μM and 0.17 μM, respectively. hAChE-IN-5 shows potent GSK3β inhibition with an IC50 value of 0.21 μM. hAChE-IN-5 is used as tau protein aggregation and Aβ1-42 self-aggregation inhibitor. hAChE-IN-5 can bind virtually with the PAS affecting Aβ aggregation, thus preventing Aβ-dependent neurotoxicity. hAChE-IN-5 can penetrate BBB and has the potential for multi-targeted anti-Alzheimer's agents research[1].
CAS Number
3007667-15-1
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; GSK-3
Type
Reference compound
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hache-in-5.html
Solubility
10 mM in DMSO
Smiles
BrC1=CC=C(C2=C3C(NN=C3N)=NC(C4=CC=C(Br)C=C4)=C2)C=C1
Molecular Formula
C18H12Br2N4
Molecular Weight
444.12
References & Citations
[1]Omnia M Waly, et al. Multi-targeted anti-Alzheimer's agents: Synthesis, biological evaluation, and molecular modeling study of some pyrazolopyridine hybrids. Eur J Med Chem. 2023 Oct 20:262:115880.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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