HAChE-IN-7

CAT: 0804-HY-157527Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-157527Size:1 Each
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Description
HAChE-IN-7 (compound 5s) is a mixed inhibitor affecting both the catalytic active site (CAS) and peripheral anionic site (PAS) of hAChE. hAChE-IN-7 displays the balanced inhibitory effect on hAChE (IC50=69.8 nM) and hBuChE (IC50=68.0 nM), and exhibits inhibitory activity against β-secretase-1 (BACE-1) (IC50=3.6 μM) . hAChE-IN-7 has the potential for Alzheimer's disease (AD) research[1].
CAS Number
[2978613-03-3]
UNSPSC
12352005
Target
Beta-secretase; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hache-in-7.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=CC(CNC(CCCCCCC(C)C)=O)=C1)OCCCCCCCNC2=C3C=CC=CC3=NC4=C2CCCC4
Molecular Formula
C38H55N3O3
Molecular Weight
601.86
References & Citations
[1]Juanyue Long, et al. Design, synthesis, and biological evaluation of novel capsaicin-tacrine hybrids as multi-target agents for the treatment of Alzheimer's disease. Bioorg Chem. 2024 Feb:143:107026.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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